Viral kinetics for individualized treatment durations

Individualized Treatment for Allergic Rhinitis

There Is Individualized Treatment . Why Not Individualized

Doctors use statistics to advance medical knowledge; we use a medical analogy to introduce statistical inference “from scratch” and to highlight an improvement. Your doctor, perhaps implicitly, predicts the effectiveness of a treatment for you based on its performance in a clinical trial; the trial patients serve as controls for you. The same logic underpins statistical inference: to identify t...

Genetics and Individualized Treatment for Colorectal Cancer

The clinical benefit of the genomics revolution is particularly evident in oncology. Genetic characterization of patients’ tumors has revealed that cancer is fundamentally a heterogeneous disease whose complex clinical course can be correlated to specific molecular profiles. Now, genomic data and tools are beginning to be translated from the laboratory to the clinic where physicians and patient...

Individualized Treatment Guidelines for Postpubertal Cryptorchidism

Cryptorchidism is a well-known congenital anomaly in children. However, its diagnosis is often delayed for reasons including patient unawareness or denial of abnormal findings in the testis. Moreover, it has been difficult to establish an optimal treatment strategy for postpubertal cryptorchidism, given the small number of patients. Unlike cryptorchidism in children, postpubertal cryptorchidism...

Performance Guarantees for Individualized Treatment Rules.

Because many illnesses show heterogeneous response to treatment, there is increasing interest in individualizing treatment to patients [11]. An individualized treatment rule is a decision rule that recommends treatment according to patient characteristics. We consider the use of clinical trial data in the construction of an individualized treatment rule leading to highest mean response. This is...